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valtrex to treat cold sores

valtrex to treat cold sores

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PHARMACOLOGICAL ACTION Protivovirusny preparation of purine acyclic nucleoside analogue, with highly selective effect on herpes viruses. Inside infected cells under the action of viral timidinkinaza virus undergoes a series of consecutive reactions of transformation of acyclovir in Mono-, di-and trifosfat aziklovira. Acyclovir triphosphate-integrated viral DNA chain and blocks its synthesis by competitive inhibition of viral DNA polymerase. In vitro, acyclovir is active against Herpes simplex type 1 and 2, Varicella zoster; higher concentrations required to inhibit virus Epstein-Barr virus. In vivo acyclovir therapeutically and prophylactically effective especially with viral infections caused by Herpes simplex.

PHARMACOKINETICS
Induction
The ingestion bioavailability of acyclovir is 15-30%. Cmax after administration of the drug inside dose 200 mg 5 times/day achieved through 1.5-2 h at 0.4 µg/ml.
Distribution
Acyclovir it penetrates into all body organs and tissues, including the brain and the skin. Linking plasma protein is 9-33% and is not dependent on its concentration in plasma. Spino-cerebellar liquid concentration is approximately 50% of its concentration in plasma. Valtrex crosses the placental barrier and accumulates in breast milk.

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Metabolised in the liver with the formation of pharmacologically inactive metabolite 9-karboksimetoksimetilguanina.

T1/2 in adults with normal renal function is 2-3 h. kidney klirens acyclovir is 75-80% of the total plasma clearance. Less than 2% of acyclovir is excreted through the intestines, about 84% return kidney in an unmodified form and 14% as metabolite.
Pharmacokinetics in special clinical situations
In patients with severe renal insufficiency T1/2-20 h, in gemodialise-3.5 h (the concentration of acyclovir in plasma is reduced to 60% of the original value).

DOSING REGIMEN
The mode set individually depending on the severity of the disease.
When treating infections of the skin and mucous membranes caused by the virus Herpes simplex type 1 and 2, adults and children over 2 years the drug appoint 200 mg 5 times/day for 5 days with intervals of 4 hours during the day and at an interval of 8 hours at night. In more severe cases of the disease might increase in the course of treatment.
As part of an integrated therapy with the express immunodeficiency, including expanded clinical picture of HIV infections (including early clinical manifestations of HIV infection and AIDS phase), after implantation of bone marrow appoint 400 mg 5 times/day.
To prevent the recurrence of infections caused by the Herpes simplex virus type 1 and 2, patients with normal immune status and in repeat diseases appoint 200 mg 4 times per day every 6:00
For the prevention of infections caused by the Herpes simplex virus type 1 and 2, adults and children over 2 years with immune deficiency, drug appoint 200 mg 4 times per day every 6 hours, maximum dose of 400 mg 5 times/day.
When treating infections caused by Varicella zoster virus, adults appoint 800 mg 5 times a day at intervals of 4 hours during the day and at an interval of 8 hours at night. Duration of treatment 7-10 days. Children older than 2 years appoint 20 mg/kg body weight 4 times/day for 5 days, children weighing more than 40 kg of the drug is prescribed in the same dosage as the adults.
In the treatment of Herpes Zoster (Herpes zoster), adults appoint 800 mg 4 times/cut every 6 hours for 5 days.
In patients with acute violations of the kidney (QC 10 mL/min) in the treatment and prevention of infections caused by the Herpes simplex virus, the drug appoint 200 mg 2 times per day with intervals of 12:00
When treating infections caused by Varicella zoster virus, patients with QC 10 mL/min product shall on 800 mg 2 times a day at intervals of 12 hours; When QC from 10 to 25 mL/min for 800 mg 3 times a day at intervals of 8:00
The drug should be taken during or immediately after a meal and drink enough water.
Ointment to be infested surface 5 times/day (over 4 hours). Duration of treatment is 5-10 days.

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SIDE EFFECTS

Digestive system: in a few cases, pain in the abdomen, nausea, vomiting, diarrhoea; seldom-tranzithornoe increase in liver enzymes, giperbilirubinemia.
Blood system: seldom-lakopenia, eritropenia.
From the central nervous system: rarely headache, weakness; in some cases, tremor, dizziness, increased fatigue, drowsiness, and hallucinations.
Allergic reactions: skin rash; rarely, allergic dermatitis (when applying ointments).
Local reactions: when applying the ointment may-redness, itching, peeling, burning or tingling.
Miscellaneous: rarely, alopecia, fever, increased levels of urea and creatinine.

valtrex to treat cold sores

CONTRAINDICATIONS

-hypersensitivity to azikloviru, gancikloviru or components of the drug;
-lactation (breastfeeding).
The caution should be appointed in preparation to dehydration, kidney failure, neurological irregularities, including in history.

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PREGNANCY AND LACTATION

Application of pregnancy is possible only if the projected benefits to the mother outweighs the potential risk to the fetus.
Valtrex crosses the placental barrier and accumulates in breast milk. If necessary, the admission of acyclovir in lactation requires interruption of breastfeeding.

SPECIAL INSTRUCTIONS
The caution should appoint drug patients with kidney dysfunction, sick elderly in connection with the increase of the half-life period aziklovira.
When applying the product to ensure that enough liquid.
It is not recommended to apply ointment on the mucous membranes of the mouth, eyes, genitals, because the evolution of expressed local inflammation.
The effectiveness of treatment in the application of ointments will be higher than before it started.
In immunocompromised patients with multiple repeated courses of treatment is sometimes sustainability viruses to azikloviru.
When taking the drug should monitor kidney function (level of blood urea and creatinine blood plasma).

OVERDOSE
Currently, the cases of drug overdose Acyclovir-Akos were reported.
PRESCRIBED DRUG INTERACTION
Together with the use of Probenecid increases the average elimination half-life and reduced clearance of acyclovir.
Together with the admission nefrotoksiceskimi drugs increases the risk of kidney disorders.
When an external application Aziklovira-Akos revealed no interactions with other drugs.

STORAGE TERMS AND CONDITIONS
Preparation in the form of tablets should be stored in a dry, dark place out of the reach of children at a temperature of no higher than 25° c. List b. shelf life-3 years.
Preparation in the form of ointment should be stored in a dry, the dark place at a temperature of 8° c to 15° c. Shelf life is 2 years.
Pharmacy terms
The drug in pill form is available by prescription.

Preparation in the form of an ointment approved for application as a non-prescription medicines.