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generic viagra us

generic viagra us

The properties and effects of the drug generic viagra differs from other similar means quick absorption into the bloodstream. The maximum concentration of the drug in the blood is a hour after taking prandial. Oily and abundant food reduces the rate of absorption of drugs by an average of 60 minutes. The volume of distribution in the organism in 105 litres indicates widespread distribution of the drug in the tissues of the body. Linking the main active ingredient of sildenafil and its circulating metabolite, N-desmetila with plasma proteins depends on the concentration of the drug and is in most cases to approximately 96%. The withdrawal of the drug from the body is made by liver microsomal enzymes CYP 3A4 and CYP2C9. By N-desmetilirovania tool is converted to active metabolite and further metabolized.

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This metabolite has a similar selectivity against PDE and in vitro activity against PDE 5 50% compared to the original medicinal substance. The main element of sildenafil comes out of the body with the urine (13%) and increasingly with faeces (87%). Pharmacokinetics of the drug Thus, while respecting the recommended dosage, the drug is not likely to cause erection in the absence of natural male sexual arousal. Frequency of use and dosage A bag with the product is designed for a single application. Divide the contents into several parts is recommended only in special cases. In order to avoid the adverse consequences associated with an overdose of medication and possible side effects, the drug should be applied strictly under the supervision of a physician. In one bag contains 50 mg of the drug is the recommended dose for most people, developed in the course of the research. To receive the medicinal product is recommended for 60 minutes before sexual intercourse. In some cases, you can take Kamagru, ranging from 30 minutes to 4:00 prior to sexual activity. The maximum dose of the drug is 100 mg. In this case, implement re-employment drug need not earlier than 24 hours.

Interaction with other drugs Testimony in vitro studies: the drug generic viagra is a weak inhibitor of cytochrome P450 isoforms 1A2, 2C9, 2C19, 2 d 6, 2E1 and 3A4 (IC50 150 mM). The likelihood that the drug is taken in the recommended dosage, affect the clearance of substrates of these isoenzymes is small. This is due to the fact that the maximum concentration of the drug in plasma is not more than 1 mm. Evidence in vivo studies: while admission to tolbutamidom (250 mg) or warfarin (40 mg), metaboliziruemah by CYP2C9 no effects have been detected. Bleeding time caused by the action of aspirin (150 mg), does not increase due to the action of the drug generic viagra. In healthy volunteers not amplified gipotenzivne effect alcohol while maximizing its content in the blood of 0.08%. Simultaneous with the drug amlodipine from hypertensive patients: the pressure in the prone position (average: systolic 8 mmHg in diastolic on 7; mmHg) has a similar magnitude as when taken just this medicine separately. Differences in the frequency of occurrence of side effects in people taking apart Kamagru, and those who take it with a hypotensive means, were not identified during the analysis of the data security of the drug generic viagra. Use during pregnancy and lactation period.

generic viagra us

This remedy is intended only for the use of men, so the question of his admission of pregnant and lactating women is not applicable. Side effects of the drug Most often: -headaches and migraine. Often: -dizziness; -short-term impairment, tsvetovospriatia, blurred vision vision, sensitivity to bright light; -excessive blood rushing to the face immediately after taking the drug, feeling heat on the face; -nasal congestion; -neuralgia. Not very often: Mydriasis, conjunctivitis, fear of light, eye hemorrhage, cataract, pain in the eyes;

-noise and pain in the ears;

-shortness of breath, cough, bronchitis, bronchial asthma, laryngitis, pharyngitis, sinusitis; a strong heartbeat, tachycardia, sinkope, lower blood pressure, postural hypotension, peripheral oedema, myocardial ischaemia, cerebral thrombosis, delayed a heart contraction, cardiac failure, abnormalities on electrocardiogram, atrioventricular blockade ventricular, angina, cardiomyopathy;

generic viagra us

is thirst, nausea, vomiting, dry mouth, stomatitis, gingivitis, Glossitis, dysphagia, esophagitis, gastritis, gastroenteritis, colitis, rectal bleeding;

-chest pain, weakness;

-back pain;

-gout, arthralgia, myalgia, tendon tears, Tenosynovitis, myasthenia, SYNOVITIS, arthritis, arthrosis;

-ataxia, neuralgia, neuropathy, paresthesia, tremor, depression, excessive sleepiness, insomnia and sleep disturbance, decreased reflexes, hypoesthesia;

-skin diseases: urticaria, herpes, skin rashes, itching of the skin, increased sweating, ulcers, contact DermIS.